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Science 16 February 2001:
Vol. 291. no. 5507, pp. 1251 - 1255
DOI: 10.1126/science.1058244
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Viewpoint
SEQUENCE INTERPRETATION:
Functional Annotation of Mouse Genome Sequences
The International Mouse Mutagenesis Consortium1: Joseph H. Nadeau,* Rudi Balling [President, International Mammalian Genome Society (IMGS)], Greg Barsh, David Beier, S. D. M. Brown, Maja Bucan, Sally Camper (Secretariat, IMGS), George Carlson, Neal Copeland, Janan Eppig, Colin Fletcher, Wayne N. Frankel, Detlev Ganten, Dan Goldowitz, Chris Goodnow, Jean-Louis Guenet (Secretariat, IMGS), Geoff Hicks, Martin Hrabe de Angelis, Ian Jackson (Vice President, IMGS), Howard J. Jacob, Nancy Jenkins, Dabney Johnson, Monica Justice (Secretariat, IMGS), Steve Kay, David Kingsley, Hans Lehrach, Terry Magnuson (Secretariat, IMGS), Miriam Meisler (Past President, IMGS), AnneMarie Poustka, Eugene M. Rinchik, Janet Rossant, Lee B. Russell, John Schimenti, Toshihiko Shiroishi (Secretariat, IMGS), William C. Skarnes, Phil Soriano, William Stanford, Joseph S. Takahashi, Wolfgang Wurst, Andreas Zimmer
With the reports of the DNA sequence of the human and mouse genomes, research attention is now on questions of protein function and interactions, developmental and physiological pathways, and systems biology. The International Mouse Mutagenesis Consortium proposes goals and outlines plans for the next 10 years for annotating the mouse genome and compiling data on mouse mutations. In addition to the challenges of identifying new assays to probe biological functions, more efficient and reliable methods are needed for archiving, managing, analyzing, displaying, and disseminating the complex phenotype data sets resulting from mutagenesis programs. Achieving these goals will require the biomedical research community to improve efficiencies, to reduce costs, and to coordinate international expertise and resources.
1The members of the IMMC are listed in (21).
*To whom correspondence should be addressed. Department of Genetics, BRB 624, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. E-mail: jhn4{at}po.cwru.edu
The viewpoints stated here reflect their personal opinions and not those of the government.
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