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Science 24 August 2001:
Vol. 293. no. 5534, pp. 1503 - 1506
DOI: 10.1126/science.1061548
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Reports

Selective Transcription and Modulation of Resting T Cell Activity by Preintegrated HIV DNA

Yuntao Wu, Jon W. Marsh*

The quiescent nature of most peripheral T cells poses an effective limitation to human immunodeficiency virus (HIV) replication and, in particular, to viral integration into the host chromatin. Two HIV proteins, Nef and Tat, increase T cell activity, but a requirement of integration for viral gene expression would preclude a role for these proteins in resting cells. Here, we report that HIV infection leads to selective transcription of the nef and tat genes before integration. This preintegration transcription in quiescent cells leads to increased T cell activation and viral replication.

Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892-4034, USA.
*   To whom correspondence should be addressed. E-mail: jon{at}codon.nih.gov

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Science. ISSN 0036-8075 (print), 1095-9203 (online)