Japanese Journal of Drug Informatics
Online ISSN : 1883-423X
Print ISSN : 1345-1464
ISSN-L : 1345-1464
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Clinical Evaluation of Therapeutic Drug Monitoring (TDM) on Antibiotic Therapy for Methicillin-resistant Staphylococcus aureus (MRSA) Infection with the Diagnosis Procedure Combination (DPC) System
Nobuyuki GotoShigeki YamadaKenji Fujimori
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2014 Volume 15 Issue 4 Pages 165-168

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Abstract

Objective: The purpose of this study was to clarify the importance of therapeutic drug monitoring (TDM) at acute care hospitals using Diagnosis Procedure Combination (DPC) data.
Methods: We used DPC data from about 3,500,000 inpatients at about 950 acute care hospitals.  The investigation period was from July 2010 to December 2010.  Patients were divided into 2 groups: TDM intervention (n=22,012); and non-TDM intervention (n=26,400).  We compared the clinical indicators (length of hospital stay, payment based on performance and drug costs) and use of antimicrobials.
Results: TDM intervention was carried out in 45.5% patients for whom an anti-MRSA agent was prescribed.  The duration of anti-MRSA agent administration was significantly longer in the TDM intervention group than in the non-TDM intervention group.  The total daily cost of anti-MRSA agents was significantly lower in the TDM intervention group than in the non-TDM intervention group.
Conclusion: Our results suggest that TDM intervention is often performed for seriously ill patients who require continuous treatment.  TDM intervention may prevent adverse reactions as a result of adjusting the dosage of the anti-MRSA agent.

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© 2014 Japanese Society of Drug Informatics
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