2014 年 52 巻 Supplement 号 p. O-192-O-193
Cell delivery is a critical step in the process of repairing damaged tissues. Age-related macular degeneration (AMD) is the leading cause of visual impairment and blindness in the elderly population, whose main complication is the development of subretinal choroidal neovascularization. Sbretinal transplantation of RPE cells to the degenerated and damaged site has attracted a great deal of attention as a relatively new approach for treating AMD. However, poor survival, distribution and integration of transplanted RPE cells to the subretinal space have limited this approach. In the meantime, development of a minimally invasive surgical procedure would bring significant benefits both to surgeons and patients. In this study we developed a micropatterned biodegradable nanosheet as a supporting material for culturing and transplanting RPE cells to the subretinal space.