Role mediators of inflammation and cells in porphyrin-induced phototoxicity

Henry W. Lim

doi:10.1117/12.978000

13 June 1989 Role mediators of inflammation and cells in porphyrin-induced phototoxicity

Henry W. Lim

Proceedings Volume 1065, Photodynamic Therapy: Mechanisms; (1989) https://doi.org/10.1117/12.978000
Event: OE/LASE '89, 1989, Los Angeles, CA, United States

Abstract

The effects of porphyrins and radiation on inflammation include activation of the complement system, generation eicosanoids from mast cells, macrophages, and endothelial cells, alteration in cutaneaous eicosanoid metabolism, activation of factor XII-dependent pathways, release of mediators from mast cells, and dermal accumulation of neutrophils. These effects contribute to the development of porphyrin-induced cutaneous inflammation, which can be seen in patients with porphyrias and as a consequence of photodynamic therapy.

Citation Download Citation

Henry W. Lim "Role mediators of inflammation and cells in porphyrin-induced phototoxicity", Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); https://doi.org/10.1117/12.978000

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