Studies on wide-field-of-view multiphoton imaging using the flexible clinical multiphoton tomograph MPTflex

Martin Weinigel; Hans Georg Breunig; Peter Fischer; Marcel Kellner-Höfer; Rainer Bückle; Karsten König

doi:10.1117/12.908733

9 February 2012 Studies on wide-field-of-view multiphoton imaging using the flexible clinical multiphoton tomograph MPTflex

Martin Weinigel, Hans Georg Breunig, Peter Fischer, Marcel Kellner-Höfer, Rainer Bückle, Karsten König

Author Affiliations +

Proceedings Volume 8226, Multiphoton Microscopy in the Biomedical Sciences XII; 82262J (2012) https://doi.org/10.1117/12.908733
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Multiphoton imaging systems are capable of high-resolution 3-D image acquisition of deep tissue. A first commercially available CE-certified biomedical system for subcelluar resolution of human skin has been launched by JenLab company with the DermaInspect^R in 2002. The demand for more flexibility caused the development of the MPTflex^R, which provides an increased flexibility and accessibility especially for clinical and cosmetic examinations. However the high resolution of clinical multiphoton tomographs are adherent with a small field-of-view (FOV) of about 360×360μm². Especially time-consuming is the relocation of areas of interest (AOI) like lesions, sweat glands or hair shafts during a multiphoton examination. This limitation can be be overcome by macroscopic large-area (wide-field-ofview) multiphoton tomography, which is tested first within this work.

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Martin Weinigel, Hans Georg Breunig, Peter Fischer, Marcel Kellner-Höfer, Rainer Bückle, and Karsten König "Studies on wide-field-of-view multiphoton imaging using the flexible clinical multiphoton tomograph MPTflex", Proc. SPIE 8226, Multiphoton Microscopy in the Biomedical Sciences XII, 82262J (9 February 2012); https://doi.org/10.1117/12.908733

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KEYWORDS

Multiphoton tomography

In vitro testing

In vivo imaging

Skin

Tissue optics

Biomedical optics

Harmonic generation

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