New porphyrin glyco-conjugates

Charles Michael Drain; Sunaina Singh; Diana Samaroo; Sebastian Thompson; Mikki Vinodu; Joao P. C. Tome

doi:10.1117/12.823855

13 July 2009 New porphyrin glyco-conjugates

Charles Michael Drain, Sunaina Singh, Diana Samaroo, Sebastian Thompson, Mikki Vinodu, Joao P. C. Tome

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 73802K (2009) https://doi.org/10.1117/12.823855
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

Porphyrins bearing sugars and other motifs are proposed for a variety of therapeutic applications. Non-hydrolysable glyco conjugates of porphyrins can be formed in rapid, room temperature reacting in greater than 90% yields from tetraperfluorophenyporphyrin. Additional functional groups can be appended using the same chemistry but different stoichiometries of the reagents. Thus sugars, amines, peptides, and cationic moieties designed to target cancer cells or other diseased or disease-causing cells are made rapidly and cleanly. These compounds can then be rapidly screened for cell uptake, or selected from combinatorial libraries by cell uptake assays using a combination of fluorescence microscopy and mass spectrometry. Modifications of the macrocycle allow fine-tuning of the photonic properties for specific medical, imaging, or biochemical applications.

Citation Download Citation

Charles Michael Drain, Sunaina Singh, Diana Samaroo, Sebastian Thompson, Mikki Vinodu, and Joao P. C. Tome "New porphyrin glyco-conjugates", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73802K (13 July 2009); https://doi.org/10.1117/12.823855

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