A discussion on validity of the diffusion theory by Monte Carlo method

Dong-qing Peng; Hui Li; Shusen Xie

doi:10.1117/12.823071

6 March 2009 A discussion on validity of the diffusion theory by Monte Carlo method

Dong-qing Peng, Hui Li, Shusen Xie

Proceedings Volume 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine; 72801P (2009) https://doi.org/10.1117/12.823071
Event: Photonics and Optoelectronics Meetings, 2008, Wuhan, China

Abstract

Diffusion theory was widely used as a basis of the experiments and methods in determining the optical properties of biological tissues. A simple analytical solution could be obtained easily from the diffusion equation after a series of approximations. Thus, a misinterpret of analytical solution would be made: while the effective attenuation coefficient of several semi-infinite bio-tissues were the same, the distribution of light fluence in the tissues would be the same. In order to assess the validity of knowledge above, depth resolved internal fluence of several semi-infinite biological tissues which have the same effective attenuation coefficient were simulated with wide collimated beam in the paper by using Monte Carlo method in different condition. Also, the influence of bio-tissue refractive index on the distribution of light fluence was discussed in detail. Our results showed that, when the refractive index of several bio-tissues which had the same effective attenuation coefficient were the same, the depth resolved internal fluence would be the same; otherwise, the depth resolved internal fluence would be not the same. The change of refractive index of tissue would have affection on the light depth distribution in tissue. Therefore, the refractive index is an important optical property of tissue, and should be taken in account while using the diffusion approximation theory.

Citation Download Citation

Dong-qing Peng, Hui Li, and Shusen Xie "A discussion on validity of the diffusion theory by Monte Carlo method", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 72801P (6 March 2009); https://doi.org/10.1117/12.823071

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KEYWORDS

Tissues

Monte Carlo methods

Refractive index

Signal attenuation

Diffusion

Optical properties

Light scattering

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