In vivo application of 2-D lateral scanning mode optical coherence tomography for glucose sensing

Roman Kuranov; Donald Prough; Veronika Sapozhnikova; Inga Cicenaite; Rinat Esenaliev

doi:10.1117/12.630840

11 November 2005 In vivo application of 2-D lateral scanning mode optical coherence tomography for glucose sensing

Roman Kuranov, Donald Prough, Veronika Sapozhnikova, Inga Cicenaite, Rinat Esenaliev

Proceedings Volume 6007, Smart Medical and Biomedical Sensor Technology III; 60070K (2005) https://doi.org/10.1117/12.630840
Event: Optics East 2005, 2005, Boston, MA, United States

Abstract

Optical Coherence Tomography (OCT) was recently proposed by our group for noninvasive, continuous monitoring of blood glucose concentration in diabetics as well as in critically ill patients (both diabetic and nondiabetic). In our previous studies we tested OCT-based glucose sensing using one-dimensional (1-D) lateral scanning of the OCT probing beam over the tissue surface. The measured OCT signal was prone to motion artifacts and had high level of speckle noise. In this study we used two-dimensional (2-D) lateral scanning of the OCT probing beam and achieved 3.6-fold reduction of the speckle noise level. We also applied a post-processing Fourier filtration technique that resulted in an additional 2-2.5-fold suppression of noise. Our data indicate that the combination of acquisition time of 30-40s and the Fourier filtration technique may provide OCT monitoring of blood glucose concentration with a sensitivity of 1mM (18 mg/dL).

Citation Download Citation

Roman Kuranov, Donald Prough, Veronika Sapozhnikova, Inga Cicenaite, and Rinat Esenaliev "In vivo application of 2-D lateral scanning mode optical coherence tomography for glucose sensing", Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 60070K (11 November 2005); https://doi.org/10.1117/12.630840

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