Photoacoustic tomography and molecular fluorescence imaging: dual modality imaging of small animal brains in vivo

Xueyi Xie; Jung-Taek Oh; Meng-Lin Li; Geng Ku; Xueding Wang; Shi Ke; Chun Li; Sergiu Similache; George Stoica D.V.M.; Lihong V. Wang

doi:10.1117/12.589670

25 April 2005 Photoacoustic tomography and molecular fluorescence imaging: dual modality imaging of small animal brains in vivo

Xueyi Xie, Jung-Taek Oh, Meng-Lin Li, Geng Ku, Xueding Wang, Shi Ke, Chun Li, Sergiu Similache, George Stoica D.V.M., Lihong V. Wang

Author Affiliations +

Proceedings Volume 5697, Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; (2005) https://doi.org/10.1117/12.589670
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

We present a dual modality imaging technique by combining photoacoustic tomography (PAT) and near-infrared (NIR) fluorescence imaging for the study of animal model tumors. PAT provides high-resolution structural images of tumor angiogenesis, and fluorescence imaging offers high sensitivity to molecular probes for tumor detection. Coregistration of the PAT and fluorescence images was performed on nude mice with M21 human melanoma cell lines with αvβ3 integrin expression. An integrin αvβ3-targeted peptide-ICG conjugated NIR fluorescent contrast agent was used as the molecular probe for tumor detection. PAT was employed to noninvasively image the brain structures and the angiogenesis associated with tumors in nude mice. Coregistration of the PAT and fluorescence images was used in this study to visualize tumor location, angiogenesis, and brain structure simultaneously.

Citation Download Citation

Xueyi Xie, Jung-Taek Oh, Meng-Lin Li, Geng Ku, Xueding Wang, Shi Ke, Chun Li, Sergiu Similache, George Stoica D.V.M., and Lihong V. Wang "Photoacoustic tomography and molecular fluorescence imaging: dual modality imaging of small animal brains in vivo", Proc. SPIE 5697, Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, (25 April 2005); https://doi.org/10.1117/12.589670

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