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A comparative analysis of spectra of diffuse reflection of the breast tissue obtained when performing operation for tumor neoplasms of the breast and during the diagnostic puncture biopsy has been done. Spectral characteristics of tissues of 74 patients with different pathology of the breast (cancer, fibroadenomas, mastopathies) have been under study. Bioptic samples received from 22 patients were examined in conditions in vitro, in 35 patients the reflection spectra were recorded in the course of operation (in vivo) and in 17 patients when performing a diagnostic puncture biopsy by means of a light probe. Spectra of pathological segments of tissues and normal ones were compared. The effect of vasoactive substances of spectral characteristics of the examined tissues was evaluated. There was obtained a diagnostic parameter evaluating integrally the character of the reflection spectrum profile. Under the influence of chemo- and radiotherapy the changes in characteristics of reflection spectra profiles of the examined tissues occur as well. The method of registration of diffuse reflections in vivo is considered to be highly sensitive, so for its further development it is necessary to elaborate the ways of preparing patients for spectral examinations in vivo, to create the data base of spectra of diffuse reflection of the normal and pathological tissues.
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