Endoscopic OCT for in-vivo imaging of precancer and cancer states of human mucosa

Alexander M. Sergeev; Valentin M. Gelikonov; Grigory V. Gelikonov; Felix I. Feldchtein; Roman V. Kuranov; Natalia D. Gladkova; Natalia M. Shakhova; Irina N. Kuznetzova; Ludmila Snopova; Arkady Denisenko; Valentin Almasov

doi:10.1117/12.297941

13 January 1998 Endoscopic OCT for in-vivo imaging of precancer and cancer states of human mucosa

Alexander M. Sergeev, Valentin M. Gelikonov, Grigory V. Gelikonov, Felix I. Feldchtein, Roman V. Kuranov, Natalia D. Gladkova, Natalia M. Shakhova, Irina N. Kuznetzova, Ludmila Snopova, Arkady Denisenko, Valentin Almasov

Author Affiliations +

Proceedings Volume 3196, Optical and Imaging Techniques for Biomonitoring III; (1998) https://doi.org/10.1117/12.297941
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

First results of endoscopic applications of optical coherence tomography for in vivo studies of human mucosa in gastrointestinal and genital tracts are presented. A novel endoscopic OCT system has ben created that is based on the integration of a sampling arm of an all-optical-fiber interferometer into standard endoscopic devices using their biopsy channel to transmit low-coherence radiation to investigated tissue. We have studied mucous membranes of esophagus, stomach and uterine cervix as typical localization for carcinomatous processes. Images of tumor tissues versus healthy tissues have been recorded and analyzed. Violations of well-defined stratified healthy mucosa structure in cancerous tissue is distinctly seen by EOCT, thus making this technique promising for early diagnosis of tumors and precise guiding of excisional biopsy.

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Alexander M. Sergeev, Valentin M. Gelikonov, Grigory V. Gelikonov, Felix I. Feldchtein, Roman V. Kuranov, Natalia D. Gladkova, Natalia M. Shakhova, Irina N. Kuznetzova, Ludmila Snopova, Arkady Denisenko, and Valentin Almasov "Endoscopic OCT for in-vivo imaging of precancer and cancer states of human mucosa", Proc. SPIE 3196, Optical and Imaging Techniques for Biomonitoring III, (13 January 1998); https://doi.org/10.1117/12.297941

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