Vaccine visualization using a zwitterionic near-infrared fluorophore (Conference Presentation)

Wataru Katagiri; Marc-André Tetrault; Homan Kang; Sinyoung Jeong; Conor L. Evans; Hak Soo Choi; Satoshi Kashiwagi

doi:10.1117/12.2545297

20 April 2020 Vaccine visualization using a zwitterionic near-infrared fluorophore (Conference Presentation)

Wataru Katagiri, Marc-André Tetrault, Homan Kang, Sinyoung Jeong, Conor L. Evans, Hak Soo Choi, Satoshi Kashiwagi

Proceedings Volume 11219, Visualizing and Quantifying Drug Distribution in Tissue IV; 1121906 (2020) https://doi.org/10.1117/12.2545297
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

There remains a paucity of methodological tools to determine the biodistribution of vaccine antigens. In response to this, we established a near-infrared (NIR) imaging method using a NIR fluorophore, ZW800-1C, conjugated with different sizes of vaccine antigens that allows for real-time monitoring of the fate of delivered vaccines in vivo. The fluorescent signal observed using the system after a model vaccine injection in mice recapitulated the size-dependent transport of the vaccine into the secondary lymphoid tissue. This methodology can be broadly applied for optimization of formulations and safety evaluation of clinical vaccines.

Conference Presentation

Citation Download Citation

Wataru Katagiri, Marc-André Tetrault, Homan Kang, Sinyoung Jeong, Conor L. Evans, Hak Soo Choi, and Satoshi Kashiwagi "Vaccine visualization using a zwitterionic near-infrared fluorophore (Conference Presentation)", Proc. SPIE 11219, Visualizing and Quantifying Drug Distribution in Tissue IV, 1121906 (20 April 2020); https://doi.org/10.1117/12.2545297

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