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9 March 2020 Quantitative multi-contrast in vivo rodent imaging with optical coherence tomography and angiography (Conference Presentation)
Destiny Hsu, Ji Hoon Kwon, Ringo Ng, Jun Song, Myeong Jin Ju, Marinko V. Sarunic
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Proceedings Volume 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV; 1122827 (2020) https://doi.org/10.1117/12.2544469
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Contrast for imaging the retinal microvasculature and the retinal pigment epithelium (RPE) is essential for pre-clinical studies of vision-robbing diseases. By integrating polarization diversity detection (PDD) with OCT angiography (OCTA), we have developed a novel quantitative multi-contrast OCT for imaging pigment in the RPE as well as flow in the retinal capillaries. An adaptive filter was developed for degree of polarization uniformity (DOPU) processing to provide improved measurements of melanin region thickness in tilted retina. The retinas of three mouse strains were imaged in vivo, with results demonstrating potential for simultaneous mapping of vasculature and melanin distribution in the RPE.
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Destiny Hsu, Ji Hoon Kwon, Ringo Ng, Jun Song, Myeong Jin Ju, and Marinko V. Sarunic "Quantitative multi-contrast in vivo rodent imaging with optical coherence tomography and angiography (Conference Presentation)", Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 1122827 (9 March 2020); https://doi.org/10.1117/12.2544469
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KEYWORDS
In vivo imaging
Optical coherence tomography
Angiography
Polarization
Imaging systems
Capillaries
Retina
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