Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors

Bridget M. Crawford; Hsin-Neng Wang; Michelle L. Bowie; Victoria L. Seewaldt; Tuan Vo-Dinh

doi:10.1117/12.2529832

9 September 2019 Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors

Bridget M. Crawford, Hsin-Neng Wang, Michelle L. Bowie, Victoria L. Seewaldt, Tuan Vo-Dinh

Author Affiliations +

Proceedings Volume 11087, Biosensing and Nanomedicine XII; 1108702 (2019) https://doi.org/10.1117/12.2529832
Event: SPIE Nanoscience + Engineering, 2019, San Diego, California, United States

Abstract

Development of simple techniques for detection of nucleic acids is essential for clinical diagnostics. MicroRNA (miRNA) have been identified as potential biomarkers in early detection of various diseases, including esophageal adenocarcinoma (EAC) and Barrett’s esophagus (BE). However, these small molecules have not been adopted into clinical practice because of challenging aspects in the lab. The technology described herein is a label-free nanoprobe referred to as “inverse molecular sentinel” (iMS) for gastrointestinal cancer diagnosis using surface-enhanced Raman scattering (SERS) detection. The results of this study provide evidence supporting the robust iMS method for miRNA sensing without the need for PCR.

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Citation Download Citation

Bridget M. Crawford, Hsin-Neng Wang, Michelle L. Bowie, Victoria L. Seewaldt, and Tuan Vo-Dinh "Direct detection of cancer biomarkers using plasmonics-based Inverse Molecular Sentinel (iMS) nanobiosensors", Proc. SPIE 11087, Biosensing and Nanomedicine XII, 1108702 (9 September 2019); https://doi.org/10.1117/12.2529832

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