Multi-wavelength time domain diffuse optical tomography for breast cancer: initial results on silicone phantoms

Edoardo Ferocino; Giuseppe Di Sciacca; Laura Di Sieno; Alberto Dalla Mora; Antonio Pifferi; Simon Arridge; Fabrizio Martelli; Paola Taroni; Andrea Farina

doi:10.1117/12.2508657

1 March 2019 Multi-wavelength time domain diffuse optical tomography for breast cancer: initial results on silicone phantoms

Edoardo Ferocino, Giuseppe Di Sciacca, Laura Di Sieno, Alberto Dalla Mora, Antonio Pifferi, Simon Arridge, Fabrizio Martelli, Paola Taroni, Andrea Farina

Author Affiliations +

Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 108741N (2019) https://doi.org/10.1117/12.2508657
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Time domain Diffuse Optical Tomography (TD-DOT) non-invasively probes the optical proprieties of biological tissue. These can be related to changes in tissue composition, thus making TD-DOT potentially valuable for cancer imaging. In particular, an application of interest is therapy monitoring for breast cancer. Thus, we developed a software tool for multiwavelength TD-DOT in reflectance geometry. While the use of multiple wavelengths probes the main components of the breast, the chosen geometry offers the advantage of linking the photon flight time to the investigated depth. We validated the tool on silicon phantoms embedding an absorbing inclusion to simulate a malignant lesion in breast tissue. Also, we exploited the a priori information on position and geometry of the inclusion by using a morphological prior constraint. The results show a good localization of the depth of inclusion but a reduced quantification. When the morphological constraint is used, though, the localization improves dramatically, also reducing surface artifacts and improving quantification as well. Still, there is room for improvement in the quantification of the “lesion” properties.

Conference Presentation

Citation Download Citation

Edoardo Ferocino, Giuseppe Di Sciacca, Laura Di Sieno, Alberto Dalla Mora, Antonio Pifferi, Simon Arridge, Fabrizio Martelli, Paola Taroni, and Andrea Farina "Multi-wavelength time domain diffuse optical tomography for breast cancer: initial results on silicone phantoms", Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108741N (1 March 2019); https://doi.org/10.1117/12.2508657

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available