Parametric study for laser hot balloon angioplasty to suppress chronic restenosis: animal experiment

Tsunenori Arai; Takayuki Miyake; Masami Sakurada; Akira Miyamoto M.D.; Kyoichi Mizuno; Makoto Kikuchi; Haruo Nakamura M.D.; Atsushi Utsumi; Kiyoshi Takeuchi

doi:10.1117/12.240029

17 May 1996 Parametric study for laser hot balloon angioplasty to suppress chronic restenosis: animal experiment

Tsunenori Arai, Takayuki Miyake, Masami Sakurada, Akira Miyamoto M.D., Kyoichi Mizuno, Makoto Kikuchi, Haruo Nakamura M.D., Atsushi Utsumi, Kiyoshi Takeuchi

Author Affiliations +

Proceedings Volume 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI; (1996) https://doi.org/10.1117/12.240029
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

To suppress restenosis after the percutaneous transluminal coronary angioplasty (PTCA), we experimentally investigated the optimum parameter setting on the combination of the balloon temperature and heating duration of our laser hot balloon catheter in rabbit model. The rabbit femoral arteries were treated by our laser hot balloon of 2.5 mm in diameter with various balloon temperatures and durations at the range from 60 to 90 deg., and from 15 to 30 seconds, respectively. The histological examination showed that high temperature (greater than 70 deg.) was necessary to suppress hyperplasia of the vessel in chronic phase. The angiography of pre- and post-treatment and of 2 months after the treatment showed that high temperature with short heating duration (15-30 s) was the best setting for chronic patency of the treated vessels. The laser hot balloon angioplasty with the above mentioned parameter setting might realize significant improvement on chronic patency after PTCA.

Citation Download Citation

Tsunenori Arai, Takayuki Miyake, Masami Sakurada, Akira Miyamoto M.D., Kyoichi Mizuno, Makoto Kikuchi, Haruo Nakamura M.D., Atsushi Utsumi, and Kiyoshi Takeuchi "Parametric study for laser hot balloon angioplasty to suppress chronic restenosis: animal experiment", Proc. SPIE 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, (17 May 1996); https://doi.org/10.1117/12.240029

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