DNASynth: a software application to optimization of artificial gene synthesis

Jan Muczyński; Robert M. Nowak

doi:10.1117/12.2280134

7 August 2017 DNASynth: a software application to optimization of artificial gene synthesis

Jan Muczyński, Robert M. Nowak

Proceedings Volume 10445, Photonics Applications in Astronomy, Communications, Industry, and High Energy Physics Experiments 2017; 104452X (2017) https://doi.org/10.1117/12.2280134
Event: Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2017, 2017, Wilga, Poland

Abstract

DNASynth is a client-server software application in which the client runs in a web browser. The aim of this program is to support and optimize process of artificial gene synthesizing using Ligase Chain Reaction. Thanks to LCR it is possible to obtain DNA strand coding defined by user peptide. The DNA sequence is calculated by optimization algorithm that consider optimal codon usage, minimal energy of secondary structures and minimal number of required LCR. Additionally absence of sequences characteristic for defined by user set of restriction enzymes is guaranteed. The presented software was tested on synthetic and real data.

Citation Download Citation

Jan Muczyński and Robert M. Nowak "DNASynth: a software application to optimization of artificial gene synthesis", Proc. SPIE 10445, Photonics Applications in Astronomy, Communications, Industry, and High Energy Physics Experiments 2017, 104452X (7 August 2017); https://doi.org/10.1117/12.2280134

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KEYWORDS

Evolutionary algorithms

Molecules

Proteins

Computer programming

Databases

Detection and tracking algorithms

Human-machine interfaces

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