An optical chip aggregometer based on laser transmission to detect alterations in the aggregation of glycosylated RBC

Martín A. Toderi; Natalia Lerda; Patricia Buszniez; Bibiana D. Riquelme

doi:10.1117/12.2273327

24 August 2017 An optical chip aggregometer based on laser transmission to detect alterations in the aggregation of glycosylated RBC

Martín A. Toderi, Natalia Lerda, Patricia Buszniez, Bibiana D. Riquelme

Author Affiliations +

Proceedings Volume 10376, Novel Optical Systems Design and Optimization XX; 103760U (2017) https://doi.org/10.1117/12.2273327
Event: SPIE Optical Engineering + Applications, 2017, San Diego, California, United States

Abstract

The study of erythrocyte (RBC) aggregation is of great interest because of its implications on human health, alterations in erythrocyte aggregation can lead to microcirculatory problems. An optical-chip based system was developed using laser transmission techniques in order to evaluate and characterize RBC aggregation. Studies are carried out with in vitro altered RBC by non-enzymatic glycosylation. Several samples were analyzed, and by computational data processing, characteristic parameters were found, describing RBC aggregation kinetics in order to improve the early detection in clinical environments of these anomalies, generally present in vascular diseases such as hypertension and diabetes.

Citation Download Citation

Martín A. Toderi, Natalia Lerda, Patricia Buszniez, and Bibiana D. Riquelme "An optical chip aggregometer based on laser transmission to detect alterations in the aggregation of glycosylated RBC", Proc. SPIE 10376, Novel Optical Systems Design and Optimization XX, 103760U (24 August 2017); https://doi.org/10.1117/12.2273327

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