Broadband time-resolved diffuse optical spectrometer for clinical diagnostics: characterization and in-vivo measurements in the 600-1350 nm spectral range

Sanathana Konugolu Venkata Sekar; Andrea Farina; Edoardo Martinenghi; Alberto Dalla Mora; Paola Taroni; Antonio Pifferi; Turgut Durduran; Marco Pagliazzi; Claus Lindner; Parisa Farzam; Mireia Mora; Mattia Squarcia; A. Urbano-Ispizua

doi:10.1117/12.2183835

16 July 2015 Broadband time-resolved diffuse optical spectrometer for clinical diagnostics: characterization and in-vivo measurements in the 600-1350 nm spectral range

Sanathana Konugolu Venkata Sekar, Andrea Farina, Edoardo Martinenghi, Alberto Dalla Mora, Paola Taroni, Antonio Pifferi, Turgut Durduran, Marco Pagliazzi, Claus Lindner, Parisa Farzam, Mireia Mora, Mattia Squarcia, A. Urbano-Ispizua

Author Affiliations +

Proceedings Volume 9538, Diffuse Optical Imaging V; 95380R (2015) https://doi.org/10.1117/12.2183835
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

We report on the design, performance assessment, and first in vivo measurement of a Time-Resolved Diffuse Optical system for broadband (600-1350 nm) nm measurement of absorption and scattering spectra of biological tissues for non-invasive clinical diagnostics. Two strategies to reduce drift and enhance responsivity are adopted. The system was enrolled in a first in vivo test phase on healthy volunteers, carrying out non-invasive, in vivo quantification of key tissue constituents (oxy- and deoxy-hemoglobin, water, lipids, collagen) and tissue micro-structure (scatterer size and density).

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Sanathana Konugolu Venkata Sekar, Andrea Farina, Edoardo Martinenghi, Alberto Dalla Mora, Paola Taroni, Antonio Pifferi, Turgut Durduran, Marco Pagliazzi, Claus Lindner, Parisa Farzam, Mireia Mora, Mattia Squarcia, and A. Urbano-Ispizua "Broadband time-resolved diffuse optical spectrometer for clinical diagnostics: characterization and in-vivo measurements in the 600-1350 nm spectral range", Proc. SPIE 9538, Diffuse Optical Imaging V, 95380R (16 July 2015); https://doi.org/10.1117/12.2183835

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