Multichannel fiber-based diffuse reflectance spectroscopy for the rat brain exposed to a laser-induced shock wave: comparison between ipsi- and contralateral hemispheres

Mai Miyaki; Satoko Kawauchi; Wataru Okuda; Hiroshi Nawashiro; Toshiya Takemura; Shunichi Sato; Izumi Nishidate

doi:10.1117/12.2078553

10 March 2015 Multichannel fiber-based diffuse reflectance spectroscopy for the rat brain exposed to a laser-induced shock wave: comparison between ipsi- and contralateral hemispheres

Mai Miyaki, Satoko Kawauchi, Wataru Okuda, Hiroshi Nawashiro, Toshiya Takemura, Shunichi Sato, Izumi Nishidate

Author Affiliations +

Proceedings Volume 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II; 930526 (2015) https://doi.org/10.1117/12.2078553
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Due to considerable increase in the terrorism using explosive devices, blast-induced traumatic brain injury (bTBI) receives much attention worldwide. However, little is known about the pathology and mechanism of bTBI. In our previous study, we found that cortical spreading depolarization (CSD) occurred in the hemisphere exposed to a laser- induced shock wave (LISW), which was followed by long-lasting hypoxemia-oligemia. However, there is no information on the events occurred in the contralateral hemisphere. In this study, we performed multichannel fiber-based diffuse reflectance spectroscopy for the rat brain exposed to an LISW and compared the results for the ipsilateral and contralateral hemispheres. A pair of optical fibers was put on the both exposed right and left parietal bone; white light was delivered to the brain through source fibers and diffuse reflectance signals were collected with detection fibers for both hemispheres. An LISW was applied to the left (ipsilateral) hemisphere. By analyzing reflectance signals, we evaluated occurrence of CSD, blood volume and oxygen saturation for both hemispheres. In the ipsilateral hemispheres, we observed the occurrence of CSD and long-lasting hypoxemia-oligemia in all rats examined (n=8), as observed in our previous study. In the contralateral hemisphere, on the other hand, no occurrence of CSD was observed, but we observed oligemia in 7 of 8 rats and hypoxemia in 1 of 8 rats, suggesting a mechanism to cause hypoxemia or oligemia or both that is (are) not directly associated with CSD in the contralateral hemisphere.

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Mai Miyaki, Satoko Kawauchi, Wataru Okuda, Hiroshi Nawashiro, Toshiya Takemura, Shunichi Sato, and Izumi Nishidate "Multichannel fiber-based diffuse reflectance spectroscopy for the rat brain exposed to a laser-induced shock wave: comparison between ipsi- and contralateral hemispheres", Proc. SPIE 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II, 930526 (10 March 2015); https://doi.org/10.1117/12.2078553

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KEYWORDS

Optical fibers

Brain

Diffuse reflectance spectroscopy

Reflectivity

Bone

Signal detection

Blood

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