Phthalocyanines as photosensitizing agents for tumors--mechanism of action

Ehud Ben-Hur

doi:10.1117/12.168667

1 March 1994 Phthalocyanines as photosensitizing agents for tumors--mechanism of action

Ehud Ben-Hur

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168667
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Aluminum phthalocyanine (AlPc) is a second-generation photosensitizer under study for photodynamic therapy (PDT) of cancer. Its mechanism of action is not known. Fluoride appears to be a powerful probe for the mechanistic study of AlPc derivatives. F^- forms a complex with the Al ligand, resulting in drastically reduced AlPc-induced phototoxicity. This is due to a modified binding of AlPc with certain target proteins, resulting in inhibition of electron transfer reactions (type I) but not singlet oxygen reactions (type II). In Chinese hamster ovary (CHO) cell membranes, Na⁺/K⁺-ATPase activity is selectively protected by F^- from photosensitized inhibition by AlPc, suggesting that this enzyme may be a critical target for AlPc-PDT. Another cellular response, not interfered with by F^-, is a transient increase of cytoplasmic free Ca²⁺ after AlPc-PDT. This increase was shown to trigger the induction of a recovery process.

Citation Download Citation

Ehud Ben-Hur "Phthalocyanines as photosensitizing agents for tumors--mechanism of action", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168667

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