Photodynamic therapy in prostate cancer: optical dosimetry and response of normal tissue

Qun Chen; Sugandh D. Shetty M.D.; Larry Heads; Frank Bolin; Brian C. Wilson; Michael S. Patterson; Larry T. Sirls II; Daniel Schultz; Joseph C. Cerny M.D.; Fred W. Hetzel

doi:10.1117/12.146314

18 June 1993 Photodynamic therapy in prostate cancer: optical dosimetry and response of normal tissue

Qun Chen, Sugandh D. Shetty M.D., Larry Heads, Frank Bolin, Brian C. Wilson, Michael S. Patterson, Larry T. Sirls II, Daniel Schultz, Joseph C. Cerny M.D., Fred W. Hetzel

Author Affiliations +

Proceedings Volume 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II; (1993) https://doi.org/10.1117/12.146314
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

The present study explores the possibility of utilizing photodynamic therapy (PDT) in treating localized prostate carcinoma. Optical properties of ex vivo human prostatectomy specimens, and in vivo and ex vivo dog prostate glands were studied. The size of the PDT induced lesion in dog prostate was pathologically evaluated as a biological endpoint. The data indicate that the human normal and carcinoma prostate tissues have similar optical properties. The average effective attenuation depth is less in vivo than that of ex vivo. The PDT treatment generated a lesion size of up to 16 mm in diameter. The data suggest that PDT is a promising modality in prostate cancer treatment. Multiple fiber system may be required for clinical treatment.

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Qun Chen, Sugandh D. Shetty M.D., Larry Heads, Frank Bolin, Brian C. Wilson, Michael S. Patterson, Larry T. Sirls II, Daniel Schultz, Joseph C. Cerny M.D., and Fred W. Hetzel "Photodynamic therapy in prostate cancer: optical dosimetry and response of normal tissue", Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); https://doi.org/10.1117/12.146314

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