Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
A Case Report of Siblings with Hemolytic Uremic Syndrome from Whose Stool E. coli O157: H7 was Isolated
Mitsuhiro ANDOU, Tetsuya ITOU, Hiromi ICHIKAWA, Fumihiko MIZUTANI, Miseho NAGAI, Akira KAWAKITA, Yoshimi SUZUKI, Yutaka NISHIMURA, Kazuhiro KOBAYASHI
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Keywords: E. coli O157: H7, verotoxin producing E. coli, hemolytic uremic syndrome
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1991 Volume 65 Issue 9 Pages 1188-1193

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Abstract

We experienced siblings of hemolytic uremic syndrome which occurred following diarrhea and bloody stool. They were immediately treated with dipyridamole and aspirin, and recovered from hemolytic uremic syndrome in about two weeks. E. coli O157: H7 (verotoxin producing E. coli) which is recently thought to be related to the pathogenesis of hemolytic uremic syndrome was isolated in their stool cultures on admission. As far as we know, this is the first case in Japan from which stool E. coli 0157: H7 was detected. Moreover, we reported clinical effectiveness of genomic investigation utilizing polymerase chain reaction method for verotoxin coding region in a rapid diagnosis of this bacterial infection.

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© The Japansese Association for Infectious Diseases
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