Donor Pretreatment with Tetrahydrobiopterin Saves Pancreatic Isografts from Ischemia Reperfusion Injury in a Mouse Model
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Key words:
Animal models
donor preconditioning
endothelial nitric oxide synthase
endothelial dysfunction
ischemia/reperfusion injury
mice
nitric oxide
oxidative stress
pancreas transplantation
Abbreviations:
b.w
body weight
CD
capillary diameter
CIT
cold ischemia time
DAB
diamonbenzidinetetrahydrochloride
FCD
functional capillary density
H4B
tetrahydrobiopterin
HCl
Hydrochloric Acid
HPLC
high pressure liquid chromatography
HTK
Histidine‐Tryptophane‐Ketoglutarate
i.d.
inner diameter
ICH
immunohistochemistry
i.m.
intramuscular
IRI
ischemia reperfusion injury
IVFM
intravital fluorescence microscopy
MW
molecular weight
NaOH
Sodium hydroxide
NO
nitric oxide
(e)(i)(n)NOS
(endothelial)(inducible)(neuronal) nitric oxide synthase
ONOO‐
peroxynitrite
PBS
Dulbecco's Phosphate buffered saline
p.o.
post operationem
SDS‐PAGE
sodium dodecyl sulfate poly‐acrylamide gel electrophoresis
WIT
warm ischemia time
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Copyright © 2010 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.