Brief CommunicationDonor-Specific Antibodies Are Produced Locally in Ectopic Lymphoid Structures in Cardiac Allografts
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KEYWORDS
translational research/science
heart transplantation/cardiology
molecular biology
pathology/histopathology
alloantibody
B cell biology
rejection: antibody-mediated (ABMR)
rejection: chronic
vasculopathy
Abbreviations
AID
activation-induced cytidine deaminase
AMR
antibody-mediated rejection
CAV
cardiac allograft vasculopathy
D
donor
DSA
donor-specific antibody
ELISA
enzyme-linked immunosorbent assay
ELS
ectopic lymphoid structures
F
female
FF
fresh frozen
H-CAV
histological cardiac allograft vasculopathy
HTx
heart transplantation
IFN-γ
interferon γ
IHC
immunohistochemistry
ISH
in situ hybridization
ISHLT
International Society of Heart and Lung Transplantation
M
male
neg
negative
pAMR
pathological antibody-mediated rejection
PCR
polymerase chain reaction
P
patient
RQ
relative quantity
TLO
tertiary lymphoid organ
TNF-α
tumor necrosis factor α
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Copyright © 2017 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.