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An in computo investigation of the Landau-Kleffner syndrome
Bonjean, M.; Phillips, C.; Thien Thanh Dang Vu; Sepulchre, R.; Maquet, P.;
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
22-26 Aug. 2007
Page(s):2730
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2734
Abstract:
We describe a computational model of the thalamus and the cortex able to reproduce some essential epileptiform features commonly observed in the Landau-Kleffner syndrome. Investigation with this realistic model leads us to the formulation of a cellular mechanism that could be responsible for the epileptic discharges occuring with this severe syndrome. Understanding this mechanism is of prime importance for developing new therapeutical strategies.
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