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Ca2+ Sparks Detection and Classification using Gaussian-Mexican Hat Wavelet
Zhi Zhou; Yingzi Du; Rodney, G.G.; Schneider, M.F.;
Image Processing, 2007. ICIP 2007. IEEE International Conference on
Volume 6,
Sept. 16 2007-Oct. 19 2007
Page(s):VI - 253
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VI - 256
Abstract:
It is evidenced that Ca2+ plays a critical role in cell activities. Understanding and analysis of a Ca2+ sparks event can provide critical information in cell communications. It is known that a Ca2+ spark spatial spread in a local area can be modeled by a Gaussian distribution. There are some available methods in Ca2+ spark detection, but little research has been done to quantitatively analyze and classify the Ca2+ sparks into single or multiple release events. In this paper, a new method based on Gaussian-Mexican Hat Wavelet is proposed to automatically classify Ca2+ sparks into single release events or multiple releases events. Then Ca2+ sparks from single release events are further categorized into different energy levels. The experiment results using mouse skeletal muscle fiber cells show this method is promising.
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