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Bioprinting in ophthalmology: current advances and future pathways

Nataraj Poomathi (Centre for Nanofibers and Nanotechnology Initiative, National University of Singapore, Singapore and Organic and Bioorganic Chemistry Division, CSIR-Central Leather Research Institute, Chennai, India)
Sunpreet Singh (School of Mechanical Engineering, Lovely Professional University, Phagwara, India)
Chander Prakash (School of Mechanical Engineering, Lovely Professional University, Jalandhar, India)
Rajkumar V. Patil (Singapore Eye Research Institute, Singapore and Okyo Pharma Ltd., Doylestown, Pennsylvania, USA)
P.T. Perumal (Organic and Bioorganic Chemistry Division, CSIR-Central Leather Research Institute, Chennai, India)
Veluchamy Amutha Barathi (Translational Preclinical Model Platform, Singapore Eye Research Institute, Singapore and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore and Ophthalmology Academic Clinical Research Program, DUKE-NUS Graduate Medical School, Singapore)
Kalpattu K. Balasubramanian (Department of Biotechnology, Indian Institute of Technology Madras, Guindy, India)
Seeram Ramakrishna (Centre for Nanofibers and Nanotechnology Initiative, National University of Singapore, Singapore)
N.U. Maheshwari (Organic and Bioorganic Chemistry Division, CSIR-Central Leather Research Institute, Chennai, India)

Rapid Prototyping Journal

ISSN: 1355-2546

Article publication date: 15 November 2018

Issue publication date: 16 April 2019

585

Abstract

Purpose

Bioprinting is a promising technology, which has gained a recent attention, for application in all aspects of human life and has specific advantages in different areas of medicines, especially in ophthalmology. The three-dimensional (3D) printing tools have been widely used in different applications, from surgical planning procedures to 3D models for certain highly delicate organs (such as: eye and heart). The purpose of this paper is to review the dedicated research efforts that so far have been made to highlight applications of 3D printing in the field of ophthalmology.

Design/methodology/approach

In this paper, the state-of-the-art review has been summarized for bioprinters, biomaterials and methodologies adopted to cure eye diseases. This paper starts with fundamental discussions and gradually leads toward the summary and future trends by covering almost all the research insights. For better understanding of the readers, various tables and figures have also been incorporated.

Findings

The usages of bioprinted surgical models have shown to be helpful in shortening the time of operation and decreasing the risk of donor, and hence, it could boost certain surgical effects. This demonstrates the wide use of bioprinting to design more precise biological research models for research in broader range of applications such as in generating blood vessels and cardiac tissue. Although bioprinting has not created a significant impact in ophthalmology, in recent times, these technologies could be helpful in treating several ocular disorders in the near future.

Originality/value

This review work emphasizes the understanding of 3D printing technologies, in the light of which these can be applied in ophthalmology to achieve successful treatment of eye diseases.

Keywords

Acknowledgements

Dr N. Poomathi would like to thank the Department of Science and Technology (DST), New Delhi, India, for the award of the Women Scientist Fellowship under Women Scientist Scheme (WOS-A).

Citation

Poomathi, N., Singh, S., Prakash, C., Patil, R.V., Perumal, P.T., Barathi, V.A., Balasubramanian, K.K., Ramakrishna, S. and Maheshwari, N.U. (2019), "Bioprinting in ophthalmology: current advances and future pathways", Rapid Prototyping Journal, Vol. 25 No. 3, pp. 496-514. https://doi.org/10.1108/RPJ-06-2018-0144

Publisher

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Emerald Publishing Limited

Copyright © 2018, Emerald Publishing Limited

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