Accurate Coarse-Grained Modeling of Red Blood Cells

Igor V. Pivkin and George Em Karniadakis
Phys. Rev. Lett. 101, 118105 – Published 12 September 2008

Abstract

We develop a systematic coarse-graining procedure for modeling red blood cells (RBCs) using arguments based on mean-field theory. The three-dimensional RBC membrane model takes into account the bending energy, in-plane shear energy, and constraints of fixed surface area and fixed enclosed volume. The coarse-graining procedure is general, it can be used for arbitrary level of coarse-graining and does not employ any fitting parameters. The sensitivity of the coarse-grained model is investigated and its behavior is validated against available experimental data and in dissipative particle dynamics (DPD) simulations of RBCs in capillary and shear flows.

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  • Received 6 September 2007

DOI:https://doi.org/10.1103/PhysRevLett.101.118105

©2008 American Physical Society

Authors & Affiliations

Igor V. Pivkin* and George Em Karniadakis

  • Division of Applied Mathematics, Brown University, Providence, Rhode Island 02912, USA

  • *piv@dam.brown.edu
  • gk@dam.brown.edu

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Issue

Vol. 101, Iss. 11 — 12 September 2008

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