Different pulling modes in DNA overstretching: A theoretical analysis

D. Marenduzzo, E. Orlandini, F. Seno, and A. Trovato
Phys. Rev. E 81, 051926 – Published 27 May 2010

Abstract

We study the thermally driven denaturation of a double-stranded polymer in the presence of a stretching force via Monte-Carlo simulations. When one strand only is stretched, the denaturation transition is first order, while when both strands are stretched, melting is second order. By revisiting the Poland-Scheraga model for DNA melting, we show that at room temperature, the most likely scenario is that DNA melts as it overstretches. Our results are in general agreement with the most recent experiments and suggest how varying temperature and stretching mode may help settle the question whether S-DNA exists or not.

  • Figure
  • Figure
  • Received 11 June 2009

DOI:https://doi.org/10.1103/PhysRevE.81.051926

©2010 American Physical Society

Authors & Affiliations

D. Marenduzzo1, E. Orlandini2,3,4, F. Seno2,3, and A. Trovato2,3

  • 1SUPA, School of Physics, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JZ, Scotland
  • 2Dipartimento di Fisica, Universita’ di Padova, 35131 Padova, Italy
  • 3CNISM, Unità di Padova, Via Marzolo 8, 35131 Padova, Italy
  • 4INFN, Sezione di Padova, Via Marzolo 8, 35131 Padova, Italy

Article Text (Subscription Required)

Click to Expand

References (Subscription Required)

Click to Expand
Issue

Vol. 81, Iss. 5 — May 2010

Reuse & Permissions
Access Options
Author publication services for translation and copyediting assistance advertisement

Authorization Required


×
×

Images

×

Sign up to receive regular email alerts from Physical Review E

Log In

Cancel
×

Search


Article Lookup

Paste a citation or DOI

Enter a citation
×