We show that voltage-sensitive macromolecules can, by the application of the right type of external voltage fluctuations, be focused with great probability into a desired kinetic substate. As an illustration we consider an eight-state model of the Shaker $K^{+}$ channel driven by dichotomous voltage fluctuations. This technique may provide a powerful new tool for the study of the kinetics of voltage sensitive ion channels.

• Received 2 June 1995

DOI:https://doi.org/10.1103/PhysRevLett.76.550