Interactions of Growth Factor Receptors with Cytoplasmic Signaling Molecules
- L.T. Williams*,†,‡,
- J.A. Escobedo†,‡,
- W.J. Fantl*,
- C.W. Turck*,‡, and
- A. Klippel*,†
This extract was created in the absence of an abstract.
Excerpt
The tyrosine kinase family of growth factor receptors initiates the transition of cells from a quiescent state (G0) through the early and middle phases of G1. Many of the receptors in this family also stimulate cell migration, changes in cell shape, production of extracellular matrix, and transcription of specific genes. Because of the apparent complexity of the cytosolic reactions that occur within minutes of the addition of a growth factor to cells, it has been difficult to determine which of the reactions mediate the mitogenic response. However, recent progress in elucidating the first steps of signal transduction have provided new approaches to unraveling the pathways and identifying the cytoplasmic molecules that lie between the receptor and DNA synthesis.
Several mechanistic features are common to most of the receptors in the tyrosine kinase family. First, most of these receptors form ligand-induced dimers (e.g., PDGF receptor, EGF receptor, FGF receptor, CSF-1 receptor)...
