TCR Recognition and Selection In Vivo
- M.M. Davis*,†,
- L.J. Berg†,
- A.Y. Lin*,†,
- B. Fazekas de St. Groth†,
- B. Devaux*,†,
- C.G. Sagerstrom†,
- P.J. Bjorkman†,‡, and
- J.F. Elliott†,§
- *Howard Hughes Medical Institute and †The Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5428; ‡Biology Division, The California Institute of Technology, Pasadena, California 95205; §The DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 95304
This extract was created in the absence of an abstract.
Excerpt
Much has been accomplished in identifying the molecules and genes responsible for T-cell recognition. We are now familiar with two distinct heterodimers, αβ and γδ, and we know that the former (at least) confers on a T cell the ability to recognize antigens complexed with specific molecules of the major histocompatibility complex (MHC) (Dembic et al. 1986; Saito and Germain 1987). Because of the recent solution of an MHC class I structure (Bjorkman et al. 1987a,b), its apparent generalization to class II molecules (Brown et al. 1988), as well as the similarity of T-cell receptor (TCR) primary sequences to immunoglobulins (Igs), we can guess a great deal about how they might interact (Chothia et al. 1988, Claverie et al. 1989; Davis and Bjorkman 1988; see also Bjorkman and Davis, this volume). These remain speculations, however, until we can derive real biochemical and structural data from the event itself (e.g., TCR-antigen-MHC...
