Progenitor-cell Populations Can Be Infected by RNA Tumor Viruses, but Transformation Is Dependent on the Expression of Specific Differentiated Functions
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Excerpt
A variety of cell types may be infected and transformed by Rous sarcoma virus (RSV) in vitro. These transformed cells lose the particular cell products that characterize them as particular cell types. Myoblasts transformed by RSV fail to fuse and to synthesize a variety of muscle-specific products (Holtzer et al. 1975; Fiszman and Fuchs 1975). Chondroblasts undergo a qualitative shift in the particular species of sulfated proteoglycan synthesized (Pacifici et al. 1977). Retinal melanoblasts destroy their melanosomes and stop synthesis of melanin (Boettiger et al. 1977). In each case examined, cell populations were infected and then examined at a time when they express their definitive phenotypes. The process of transformation by RSV suppresses the expression of the differentiated cell program, but it does not appear to affect the program itself. In fact, the program itself is remarkably stable even during the time its expression is suppressed by cell transformation...
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