Genomic Location of Mouse Mammary Tumor Virus Proviral DNA in Normal Mouse Tissue and in Mammary Tumors
This extract was created in the absence of an abstract.
Excerpt
The mouse mammary tumor virus (MMTV) can be transmitted as an exogenous virus or an endogenous virus. The endogenous virus is passed to the offspring via the germ cell and is present as proviral DNA integrated into the genomic DNA in all cells of the mouse. In all but the GR mouse strain, these vertically transmitted proviral sequences do not seem to be involved in early mammary tumor formation. The exogenous virus is transmitted by the milk of certain strains of mice, such as the C3H strain. This milk-transmitted virus has been implicated in early tumor formation in these strains with a high incidence of mammary tumors (Hilgers and Bentvelzen 1978).
All tested inbred strains of mice contain MMTV proviral DNA sequences (Varmus et al. 1972; Scolnick et al. 1974; Michalides et al. 1976; Morris et al. 1977). The origin and the function of these sequences remain speculative. A comparative...
