ZAP-70: An Essential Kinase in T-cell Signaling
- Haopeng Wang,
- Theresa A. Kadlecek,
- Byron B. Au-Yeung,
- Hanna E. Sjölin Goodfellow,
- Lih-Yun Hsu,
- Tanya S. Freedman and
- Arthur Weiss
- Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, San Francisco, California 94143
- Correspondence: aweiss{at}medicine.ucsf.edu
Abstract
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.
Footnotes
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Editors: Lawrence E. Samelson and Andrey Shaw
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Additional Perspectives on Immunoreceptor Signaling available at www.cshperspectives.org
- Copyright © 2010 Cold Spring Harbor Laboratory Press; all rights reserved
