Molecular Analysis of Human X-linked Diseases
This extract was created in the absence of an abstract.
Excerpt
Many genes and phenotypes have been mapped to the human X chromosome because of their characteristic sex-linked mode of inheritance in families (McKusick 1983). Thus, some 100 disease loci and at least 100 DNA markers have been localized to the human X chromosome in recent years (Goodfellow et al. 1985). Until a few years ago, only two main linkage groups were established, one localized at Xpter and the other at Xqter (McKusick and Ruddle 1977). With the advent of DNA recombinant technology and the application of restriction-fragment-length polymorphisms (RFLPs) as genetic markers, it has been possible to construct a map spanning the entire human X chromosome (Botstein et al. 1980; Drayna and White 1985). Markers are sufficiently well distributed along the chromosome to enable the mapping of almost any common sex-linked disorder. In particular, some of these have been used for the development of markers for the carrier detection and...
