The Cytology of Rous Sarcoma Virus Infection
This extract was created in the absence of an abstract.
Excerpt
INTRODUCTION
Rous sarcoma virus (RSV) occupies a position which lies between the cytocidal viruses on the one hand and the viruses causing inapparent infections on the other. A chick embryo culture shows definite cytopathic changes after infection with RSV. However, the infected cells do not die. They continue to multiply, and their daughter cells remain infected.
Under well defined culture conditions the cytological changes in chick fibroblasts following infection with RSV in vitro bear close resemblance to the induction of sarcomas by RSV in vivo (Manaker and Groupé, 1956; Temin and Rubin, 1958).
The chick fibroblast, which normally grows in an elongated and flattened shape attached to the bottom of the culture dish becomes rounded and detached from the glass after infection with RSV. It shows a tendency to unrestricted growth, resulting in characteristic piles of rounded cells on the culture dish. In this report particular emphasis is given to...
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↵* Present address: Department of Pathology, University of Colorado Medical School, Denver, Colorado.
