Mediodorsal Thalamic Lesions Impair Trace Eyeblink Conditioning in the Rabbit

  1. Donald A. Powell1,2,3,4 and
  2. John Churchwell1,2
  1. 1Shirley L. Buchanan Neuroscience Laboratory, Dorn VA Medical Center and 2Department of Psychology, University of South Carolina, Columbia, South Carolina 29208, USA 3Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA

Abstract

Rabbits received lesions of the mediodorsal nucleus of the thalamus (MDN) or sham lesions and were subjected to classical eyeblink (EB) and heart rate (HR) conditioning. All animals received trace conditioning, with a .5-sec tone conditioned stimulus, a .5-sec trace period, and a 50-msec periorbital shock unconditioned stimulus. Animals with MDN lesions acquired the EB conditioned response (CR) more slowly than sham-lesioned animals. However, previous studies have shown that MDN damage does not affect delay conditioning using either .5-sec or 1-sec interstimulus intervals. The lesions had no significant effect on the HR CR. These results suggest that information processed by MDN and relayed to the prefrontal cortex is required for somatomotor response selection under nonoptimal learning conditions.

Footnotes

  • 4 Corresponding author.

  • E-MAIL donnie.powell{at}med.va.gov; FAX (803) 695-7942.

  • Article and publication are at http://www.learnmem.org/cgi/doi/10.1101/lm.45302.

    • Received November 8, 2001.
    • Accepted January 24, 2002.
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