Associative retrieval processes in the human medial temporal lobe: Hippocampal retrieval success and CA1 mismatch detection
- 1Department of Psychology, Stanford University, Stanford, California 94305, USA
- 2Rotman Research Institute, Toronto, Ontario, M6A 2E1, Canada
- 3Department of Psychology and Center for Learning & Memory, University of Texas at Austin, Austin, Texas 78712, USA
- 4Neurosciences Program, Stanford University, Stanford, California 94305, USA
- 5Department of Radiology, Stanford University, Stanford, California 94305, USA
Abstract
Hippocampal subfields CA3 and CA1 are hypothesized to differentially support the generation of associative predictions and the detection of associative mismatches, respectively. Using high-resolution functional MRI, we examined hippocampal subfield activation during associative retrieval and during subsequent comparisons of memory to matching or mismatching decision probes. Activity in the dentate gyrus/CA2/3, CA1, and other medial temporal lobe subregions tracked associative retrieval success, whereas activity in CA1 and the perirhinal cortex tracked the presence of associative mismatches. These data support the hypothesis that CA1 acts as a “comparator,” detecting when memory for the past and sensory input in the present diverge.
Footnotes
-
↵6 Corresponding author.
E-mail kanile{at}stanford.edu
- Received January 5, 2011.
- Accepted June 8, 2011.
- © 2011 Cold Spring Harbor Laboratory Press
