Spindly attachments

Filiz Çivril; Andrea Musacchio

doi:10.1101/gad.1719208

Spindly attachments

Filiz Çivril1 and
Andrea Musacchio1,2,3

¹ Department of Experimental Oncology, European Institute of Oncology, I-20139 Milan, Italy;
² Research Unit of the Italian Institute of Technology (IIT) Foundation at the IFOM-IEO Campus, I-20139 Milan, Italy

Abstract

The attachment of chromosomes to spindle microtubules during mitosis is a delicate and intricate process on which eukaryotic cells critically depend to maintain their ploidy. In this issue of Genes & Development, Gassmann and colleagues (pp. 2385–2399 present an analysis of the recently discovered Spindly/SPDL-1 protein that casts new lights onto the attachment process and the way it relates to the control of cell cycle progression.

Keywords

Footnotes

↵3 Corresponding author.

↵3 E-MAIL andrea.musacchio@ifom-ieo-campus.it; FAX 39-02-57489851.
Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1719208.