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Vol. 16, No. 22, pp. 2879-2892, November 15, 2002

RESEARCH PAPER
The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior

Brigitte Dauwalder, Susan Tsujimoto, Jason Moss, and William Mattox1

Department of Molecular Genetics, University of Texas, M.D. Anderson Cancer Center, Houston, Texas 77030, USA

The Drosophila somatic sex-determination regulatory pathway has been well studied, but little is known about the target genes that it ultimately controls. In a differential screen for sex-specific transcripts expressed in fly heads, we identified a highly male-enriched transcript encoding Takeout, a protein related to a superfamily of factors that bind small lipophilic molecules. We show that sex-specific takeout transcripts derive from fat body tissue closely associated with the adult brain and are dependent on the sex determination genes doublesex (dsx) and fruitless (fru). The male-specific Doublesex and Fruitless proteins together activate Takeout expression, whereas the female-specific Doublesex protein represses takeout independently of Fru. When cells that normally express takeout are feminized by expression of the Transformer-F protein, male courtship behavior is dramatically reduced, suggesting that male identity in these cells is necessary for behavior. A loss-of-function mutation in the takeout gene reduces male courtship and synergizes with fruitless mutations, suggesting that takeout plays a redundant role with other fru-dependent factors involved in male mating behavior. Comparison of Takeout sequences to the Drosophila genome reveals a family of 20 related secreted factors. Expression analysis of a subset of these genes suggests that the takeout gene family encodes multiple factors with sex-specific functions.

[Key Words: Sex determination; courtship behavior; fat body; gene family; doublesex; fruitless]

1 Corresponding author.

GENES & DEVELOPMENT 16:2879-2892 © 2002 by Cold Spring Harbor Laboratory Press  ISSN 0890-9369/02 $5.00
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