Cell-surface Molecules That Characterize Different Stages in the Development of Cerebellar Interneurons
- W.B. Stallcup,
- L. Beasley, and
- J. Levine
This extract was created in the absence of an abstract.
Excerpt
Developmental neurobiologists have become increasingly interested in the use of monoclonal antibodies to identify cell-type-specific cell-surface molecules. These molecules can serve as markers to aid in identifying particular cell types and tracing their developmental lineages in the nervous system. Moreover, these molecules may participate in the cell-cell recognition and interactions that are thought to mediate processes such as cell migration, aggregation, axonal pathfinding, and synaptogenesis.
We have identified two antigenic cell-surface components, the D1.1 ganglioside and the NG2 proteoglycan, that are expressed sequentially on developmentally related populations of cells in the rat cerebellar cortex. The D1.1 ganglioside is present on neuroepithelial stem cells of the external granule cell layer (EGL) but is not found on any of the differentiated progeny derived from the EGL. In contrast, the NG2 proteoglycan is not present on cells of the EGL but appears on two differentiated cell types derived from the EGL, the stellate...
