|
 |
TheScientificWorldJOURNAL (ISSN 1537-744X) |
|
|
|
|
|
| |
| |
Title: |
|
From the Behavioral Pharmacology of Beta-Carbolines to Seizures, Anxiety, and Memory |
|
| |
Authors: |
|
Venault, Patrice ; Chapouthier, Georges |
|
| |
Journal: |
|
TheScientificWorldJOURNAL |
|
| |
Year: |
|
2007 |
|
| |
Volume: |
|
7 |
|
| |
Page Range: |
|
204-223 |
|
| |
Article Type: |
|
Review Article |
|
| |
Handling Editor: |
|
Wim E. Crusio |
|
| |
Domains: |
|
Neuroscience
,
Behavior
,
Learning & Memory
|
|
| |
DOI: |
|
10.1100/tsw.2007.48 |
|
 ?
|
Article clouds not enabled. Press the image to enable for this session.
|
| |
Synopsis: |
|
Certain beta-carbolines have pharmacological properties that produce effects opposite to those of benzodiazepines. The study of these properties included observations of the behavior of two mouse strains selected for their sensitivity/resistance to a beta-carboline, and led to a physiological hypothesis: there may be an organic link between seizures and certain types of anxiety and memory processes, operating through the GABA-A receptor complex. |
|
| |
Keywords: |
|
GABA-A, benzodiazepine receptor, beta-CCM, methyl beta-carboline-3-carboxylate, selected strains, mouse, behavior, neurogenetics, pharmacogenetics, epilepsy, seizures, anxiety, learning, memory, aggression, balance disorders |
|
| |
|
|
|
|
| |
|
|
[Full Text PDF]
[Related TSW Articles]
[Export to EndNote]
[Open Choice]
|
|
| |
|
|
|
|
| |
|
|
Abstract |
|
| |
|
|
A number of beta-carbolines are inverse agonists of the GABA-A receptor complex, acting on the benzodiazepine site. They show convulsive properties when administered at high doses, anxiogenic properties at moderate doses, and learning-enhancing effects at low doses. These data suggest a possible physiological relationship, through the GABA-A receptor channel, between memory processes, anxiety, and ultimately, in pathological states, epileptic seizures. This relationship seems to be confirmed partially by experiments on mouse strains selected for their resistance (BR) and sensitivity (BS) to a single convulsive dose of a beta-carboline. These two strains also show differences in anxiety and learning abilities. However, some opposite results found while observing the behavior of the two strains suggest that in addition to pharmacologically induced anxiety, there is spontaneous anxiety, no doubt involving other brain mechanisms. |
|
| |
|
|
Related articles in:
|
|
| |
|
|
|
|
| |
|
|
| |
Post Your Comment |
 |
|
|
| |
|
|
|
|
| |
|
|
|
|
| |
|
|
|
|
|
|
|
|