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J Med Microbiol 56 (2007), 650-653; DOI: 10.1099/jmm.0.46664-0
© 2007 Society for General Microbiology
ISSN 1473-5644

Association between fluconazole susceptibility and genetic relatedness among Candida tropicalis isolates in Taiwan

Jang-Shiun Wang1,2, Shu-Ying Li3, Yun-Liang Yang4, Hsiao-Hui Chou3 and Hsiu-Jung Lo2

1 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China

2 Division of Clinical Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, Republic of China

3 Division of Laboratory Research and Development, Center for Disease Control, Taipei, Taiwan, Republic of China

4 Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, Republic of China

Correspondence
Hsiu-Jung Lo
hjlo{at}nhri.org.tw

Received 6 April 2006
Accepted 2 January 2007

Among the 162 Candida tropicalis isolates collected in the Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 1999, 23 (14.2 %) had fluconazole MICs ≥64 mg l–1, and thus fulfilled the definition of resistance. Random amplified polymorphic DNA assay showed that all 23 fluconazole-resistance C. tropicalis isolates collected from different hospitals around Taiwan were closely related. Two distinct pulsotypes associated with fluconazole susceptibility were identified when these 23 resistant isolates, along with 13 susceptible ones, were analysed by PFGE.

Abbreviations: RAPD, random amplified polymorphic DNA; TSARY, Taiwan Surveillance of Antimicrobial Resistance of Yeasts.






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