1887

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Volume 65, Issue 12

Prevention of herpes zoster and its complications: from the clinic to the real-life experience with the vaccine Free

Abstract

The erpes zoster is an acute viral illness characterized by a vesicular rash of unilateral distribution, which can eventually cause severe complications, such as post-herpetic neuralgia, ophthalmic zoster, stroke or other neurological complications. In Europe, an incidence of between 2.0 and 4.6 cases per 1000 person-years is estimated, with an increase after 50 years of age. Currently, the therapeutic options for are only partially effective in limiting the acute phase, while the management of complications is frequently complex and not satisfactory. The overall burden of the disease and the elevated costs associated with diagnosis and clinical and therapeutic management led to the development of a new preventive approach through a live attenuated virus vaccine. The vaccine now available decreases the incidence of the disease, post-herpetic neuralgia and the burden of illness. Moreover, the vaccine is safe and well tolerated and it seems to confer long-term protection. Based on the clinical results and evidence provided by the Health Technology Assessment, several countries introduced immunization although with different recommendations and methods of funding.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Herpes Zoster , Postherpetic Neuralgia , Prevention and Vaccine
© 2016 The Authors
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2016-12-16
2024-04-18
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References

  1. Autonomous Province of Trento 2016; Update of immunization schedule. Available at http://www.delibere.provincia.tn.it/scripts/gethtmlDeli.asp?Item=0&Type=HTML(Accessed: 4 July 2016) Available at: http://bur.regione.veneto.it/BurvServices/pubblica/DettaglioDgr.aspx?id=281075 Accessed: 4 July 2016
  2. Bonanni P., Azzari C., Castiglia P., Chiamenti G., Conforti G., Conversano M., Corsello G., Ferrera G., Ferro A. et al. 2014; [The 2014 lifetime immunization schedule approved by the Italian scientific societies. Italian Society of Hygiene, Preventive Medicine, and Public Health. Italian Society of Pediatrics. Italian Federation of Pediatric Physicians. Italian Federation of General Medical Physicians. Arezzo Service of Legal Medicine]. Epidemiol Prev 38:131–146[PubMed]
     [Google Scholar]
  3. Bricout H., Perinetti E., Marchettini P., Ragni P., Zotti C. M., Gabutti G., Volpi A., Franco E. 2014; Burden of herpes zoster-associated chronic pain in Italian patients aged 50 years and over (2009-2010): a GP-based prospective cohort study. BMC Infect Dis 14:637 [View Article][PubMed]
     [Google Scholar]
  4. Calabria Region 2015; Improvement of vaccination coverage in different age groups. Available at http://www.regione.calabria.it/sanita/allegati/dca_2015/dca_n._43_del_21.05.2015_-_copertura_vaccinale.pdf Accessed: 4 July 2016
  5. Coretti S., Ruggeri M., Codella P. 2014; Cost effectiveness analysis of a vaccine to prevent herpes zoster and postherpetic neuralgia in Italy. Value Health 17:A511 [View Article][PubMed]
     [Google Scholar]
  6. Donahue J. G., Choo P. W., Manson J. E., Platt R. 1995; The incidence of herpes zoster. Arch Intern Med 155:1605 [View Article][PubMed]
     [Google Scholar]
  7. Dworkin R. H., Gnann J. W., Oaklander A. L., Raja S. N., Schmader K. E., Whitley R. J. 2008; Diagnosis and assessment of pain associated with herpes zoster and postherpetic neuralgia. J Pain 9:37–44 [View Article]
     [Google Scholar]
  8. EUnetHTA 2013; Pilot of rapid assessment on ‘Zostavax for the prevention herpes zoster’. Available at http://www.eunethta.eu/news/pilot-rapid-assessment-zostavax-prevention-herpes-zoster-available Accessed: 4 July 2016
  9. Fashner J., Bell A. L. 2011; Herpes zoster and postherpetic neuralgia: prevention and management. Am Fam Physician 83:1432–1437[PubMed]
     [Google Scholar]
  10. Friuli Venezia Giulia Region 2014; Regional Council resolution n. 2535 ‘Upgrading and extension of the immunization offer in the Friuli Venezia Giulia Region’. Available at http://mtom.regione.fvg.it/storage/2014_2535/Testo%20integrale%20della%20Delibera%20n%202535-2014.pdf Accessed: 4 July 2016
  11. Gabutti G., Serenelli C., Sarno O., Marconi S., Corazza M., Virgili A. 2010; Epidemiologic features of patients affected by herpes zoster: database analysis of the Ferrara University Dermatology Unit, Italy. Med Mal Infect 40:268–272 [View Article][PubMed]
     [Google Scholar]
  12. Gershon A. A., Gershon M. D., Breuer J., Levin M. J., Oaklander A. L., Griffiths P. D. 2010; Advances in the understanding of the pathogenesis and epidemiology of herpes zoster. J Clin Virol 48:S2–S7 [View Article][PubMed]
     [Google Scholar]
  13. Gialloreti L. E., Merito M., Pezzotti P., Naldi L., Gatti A., Beillat M., Serradell L., di Marzo R., Volpi A. 2010; Epidemiology and economic burden of herpes zoster and post-herpetic neuralgia in Italy: a retrospective, population-based study. BMC Infect Dis 10:230 [View Article][PubMed]
     [Google Scholar]
  14. Gross G., Schöfer H., Wassilew S., Friese K., Timm A., Guthoff R., Pau H. W., Malin J. P., Wutzler P., Doerr H. W. 2003; Herpes zoster guideline of the German Dermatology Society (DDG). J Clin Virol 26:277–289[PubMed]
     [Google Scholar]
  15. Harpaz R., Ortega-Sanchez I. R., Seward J. F. 2008; Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 57:1–30
     [Google Scholar]
  16. HCSP (Haut Conseil de la Santé Publique) report 2013 Available at http://39.HCSP report, available athttp://www.hcsp.fr/explore.cgi/avisrapportsdomaine?clefr=390 (Accessed: 4 July 2016)
  17. Irwin M., Costlow C., Williams H., Artin K. H., Chan C. Y., Stinson D. L., Levin M. J., Hayward A. R., Oxman M. N. 1998; Cellular immunity to varicella-zoster virus in patients with major depression. J Infect Dis 178:S104–S108 [View Article][PubMed]
     [Google Scholar]
  18. Johnson R. W., Whitton T. L. 2004; Management of herpes zoster (shingles) and postherpetic neuralgia. Expert Opin Pharmacother 5:551–559 [View Article][PubMed]
     [Google Scholar]
  19. Johnson R. W. 2007; Zoster-associated pain: what is known, who is at risk and how can it be managed?. Herpes 14:30–34[PubMed]
     [Google Scholar]
  20. Johnson R. W., Wasner G., Saddier P., Baron R. 2007; Postherpetic neuralgia: epidemiology, pathophysiology and management. Expert Rev Neurother 7:1581–1595 [View Article]
     [Google Scholar]
  21. Johnson R. W., Bouhassira D., Kassianos G., Leplège A., Schmader K. E., Weinke T. 2010; The impact of herpes zoster and post-herpetic neuralgia on quality-of-life. BMC Med 8:37 [View Article][PubMed]
     [Google Scholar]
  22. Katz J., Cooper E. M., Walther R. R., Sweeney E. W., Dworkin R. H. 2004; Acute pain in herpes zoster and its impact on health-related quality of life. Clin Infect Dis 39:342–348 [View Article][PubMed]
     [Google Scholar]
  23. Langan S. M., Smeeth L., Margolis D. J., Thomas S. L. 2013; Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study. PLoS Med 10:e1001420 [View Article][PubMed]
     [Google Scholar]
  24. Levin M. J., Smith J. G., Kaufhold R. M., Barber D., Hayward A. R., Chan C. Y., Chan I. S., Li D. J., Wang W. et al. 2003; Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccine. J Infect Dis 188:1336–1344 [View Article][PubMed]
     [Google Scholar]
  25. Liguria Region 2014; Update Regional Prevention Plan. Available at http://www.asl5.liguria.it/Portals/0/Comunicati/20150409_piano%20regionale%20vaccini%20liguria%202014.pdf Accessed: 4 July 2016
  26. Lu P. J., Euler G. L., Harpaz R. 2011; Herpes zoster vaccination among adults aged 60 years and older, in the U.S., 2008. Am J Prev Med 40:e1–e6 [View Article][PubMed]
     [Google Scholar]
  27. Lukas K., Edte A., Bertrand I. 2012; The impact of herpes zoster and post-herpetic neuralgia on quality of life: patient-reported outcomes in six European countries. Z Gesundh Wiss 20:441–451 [View Article][PubMed]
     [Google Scholar]
  28. Marin M., Yawn B. P., Hales C. M., Wollan P. C., Bialek S. R., Zhang J., Kurland M. J., Harpaz R. 2015; Herpes zoster vaccine effectiveness and manifestations of herpes zoster and associated pain by vaccination status. Hum Vaccin Immunother 11:1157–1164 [View Article][PubMed]
     [Google Scholar]
  29. Molise Region 2015; Regional immunization offering 2015-2016. Available at http://www3.regione.molise.it/flex/cm/pages/ServeAttachment.php/L/IT/D/5%252Fc%252F1%252FD.5cf3a1ec54145aa197e0/P/BLOB%3AID%3D13619/E/pdf Accessed: 4 July 2016
  30. Morrison V. A., Johnson G. R., Schmader K. E., Levin M. J., Zhang J. H., Looney D. J., Betts R., Gelb L., Guatelli J. C. et al. 2015; Long-term persistence of zoster vaccine efficacy. Clin Infect Dis 60:900–909 [View Article][PubMed]
     [Google Scholar]
  31. Murray A. V., Reisinger K. S., Kerzner B., Stek J. E., Sausser T. A., Xu J., Wang W. W., Chan I. S., Annunziato P. W., Parrino J. 2011; Safety and tolerability of zoster vaccine in adults ≥60 years old. Hum Vaccin 7:1130–1136 [View Article][PubMed]
     [Google Scholar]
  32. Okamoto S., Hata A., Sadaoka K., Yamanishi K., Mori Y. 2009; Comparison of varicella-zoster virus-specific immunity of patients with diabetes mellitus and healthy individuals. J Infect Dis 200:1606–1610 [View Article][PubMed]
     [Google Scholar]
  33. Opstelten W., Zaal M. J. 2005; Managing ophthalmic herpes zoster in primary care. BMJ 331:147–151 [View Article][PubMed]
     [Google Scholar]
  34. Oxman M. N. 1995; Immunization to reduce the frequency and severity of herpes zoster and its complications. Neurology 45:S41–S46 [View Article][PubMed]
     [Google Scholar]
  35. Oxman M. N., Levin M. J., Johnson G. R., Schmader K. E., Straus S. E., Gelb L. D., Arbeit R. D., Simberkoff M. S., Gershon A. A. et al. 2005; A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med 352:2271–2284 [View Article][PubMed]
     [Google Scholar]
  36. Pinchinat S., Cebrián-Cuenca A. M., Bricout H., Johnson R. W. 2013; Similar herpes zoster incidence across Europe: results from a systematic literature review. BMC Infect Dis 13:170 [View Article][PubMed]
     [Google Scholar]
  37. Public Health England 2013; Herpes zoster (shingles) immunisation programme 2013/2014: Report for England. Available at https://www. gov.uk/government/uploads/system/uploads/attachment_data/file/383018/ShinglesReport2014.pdf Accessed: 4 July 2016
  38. Schmader K. 2001; Herpes zoster in older adults. Clin Infect Dis 32:1481–1486 [View Article][PubMed]
     [Google Scholar]
  39. Schmader K. E., Levin M. J., Gnann J. W., McNeil S. A., Vesikari T., Betts R. F., Keay S., Stek J. E., Bundick N. D. et al. 2012a; Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years. Clin Infect Dis 54:922–928 [View Article]
     [Google Scholar]
  40. Schmader K. E., Oxman M. N., Levin M. J., Johnson G., Zhang J. H., Betts R., Morrison V. A., Gelb L., Guatelli J. C. et al. 2012b; Persistence of the efficacy of zoster vaccine in the shingles prevention study and the short-term persistence substudy. Clin Infect Dis 55:1320–1328 [View Article]
     [Google Scholar]
  41. Sicily Region 2015; Amending and supplementing the immunization schedule for Life. D.A. n° 38/2015. Available at http://pti.regione.sicilia.it/portal/page/portal/PIR_PORTALE/PIR_LaStrutturaRegionale/PIR_AssessoratoSalute/PIR_Decreti/PIR_Decreti2015/PIR_Decretiassessorialianno2015/12%2001%202015%20SERV%201%20(38).pdf Accessed on 4 July 2016
  42. Tseng H. F., Tartof S., Harpaz R., Luo Y., Sy L. S., Hetcher R. C., Jacobsen S. J. 2014; Vaccination against zoster remains effective in older adults who later undergo chemotherapy. Clin Infect Dis 59:913–919 [View Article][PubMed]
     [Google Scholar]
  43. Veneto Region 2014; Approval of the new immunization schedule of Veneto Region. Regional Council Deliberation n. 1564 in Regional Official Bulletin n. 89 of 12 September 2014
  44. Volpi A. 2007; Severe complications of herpes zoster. Herpes 14:35–39[PubMed]
     [Google Scholar]
  45. Yawn B. P., Saddier P., Wollan P. C., St Sauver J. L., Kurland M. J., Sy L. S. 2007; A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction. Mayo Clin Proc 82:1341–1349 [View Article][PubMed]
     [Google Scholar]
  46. Yawn B. P., Gilden D. 2013; The global epidemiology of herpes zoster. Neurology 81:928–930 [View Article][PubMed]
     [Google Scholar]
  47. Zhang J., Xie F., Delzell E., Chen L., Winthrop K. L., Lewis J. D., Saag K. G., Baddley J. W., Curtis J. R. 2012; Association between vaccination for herpes zoster and risk of herpes zoster infection among older patients with selected immune-mediated diseases. JAMA 308:43–49 [View Article][PubMed]
     [Google Scholar]
  48. Zostavax SPC Zostavax® 2016; Summary of Product Characteristics. Annex I. Available at http://ec.europa.eu/health/documents/community-register/2006/2006051911419/anx_11419_it.pdf Accessed on 4 July 2016
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