LETTERS TO THE EDITOR
EXCESSIVE MASTURBATION AND HYPERSEXUAL BEHAVIOR ASSOCIATED WITH METHYLPHENIDATE

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    Some placebo-controlled studies showed a little increase of ED (‹1–4%) and of decreased sexual desire (1,4–4%) with methyphenidate62 or amphetamine salts.63,64 As for atomoxetine, some case reports also found in minors and/or adults under methylphenidate or amphetamine salts spontaneous erections, excessive masturbation, spontaneous ejaculation, and priapism.58,60,65–70 The fact that Bijlenga et al17 found no differences in the prevalence of sexual disorders, between patients with ADHD with pharmacological treatments and without, could suggest that there is no positive or negative impact on sexuality.

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    These are rare and usually of acute onset, and they may occur in the context of underlying psychotic disorder or substance abuse (65A). A 7-year-old girl with ADHD and mild mental retardation displayed excessive masturbation and hypersexual behavior during methylphenidate therapy (66A). After withdrawal of methylphenidate, her ADHD symptoms increased as expected, but her sexual behavior improved rapidly and disappeared completely in 1 week.

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