BASIC RESEARCH—TECHNOLOGYPhysical and Chemical Properties of Chlorhexidine and Calcium Hydroxide-Containing Medications
Section snippets
Medications
The physicochemical properties of CHX and calcium hydroxide-containing medications in different concentrations and combinations were evaluated. Medications were prepared by the following method. The required mass of methylcellulose (1 g/100 ml) (methylcellulose 4000 USP lot #PG15012N11; Medica Pharmaceutique, Montreal, Canada) was added to water and stirred until dissolution. Calcium hydroxide (USP lot #50K0121; Sigma Chemical Co., St. Louis, MO) at a concentration of 40 g/100 ml (to follow the
RESULTS
The means and SD of the pH, contact angle, and working time are shown in Table 1.
DISCUSSION
In this study, the physicochemical properties of different intra-canal medications were evaluated. There are no previous reports regarding the ideal physicochemical properties that an intracanal dressing should achieve. The different concentrations and modes of application of the medications likely affect the physical properties and subsequently the antibacterial activity of the CHX-calcium hydroxide–containing medications. No studies concerning this relationship have been reported. The
References (30)
- et al.
The effects of surgical exposure of dental pulps in germ-free and conventional rats
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(1965) - et al.
Bacteriologic evaluation of the efficacy of mechanical root canal instrumentation in endodontic therapy
Scand J Dent Res
(1981) - et al.
Effects of extensive apical reaming and calcium hydroxide dressing on bacterial infection during treatment of apical periodontitis: a pilot study
Int Endod J
(1991) - et al.
Effects of instrumentation, irrigation and dressing with calcium hydroxide on infection in pulpless teeth with periradicular bone lesions
Int Endod J
(2002) - et al.
Factors affecting the long-term results of endodontic treatment
J Endodon
(1990) - et al.
The role of intracanal medication in root canal treatment
Int Endod J
(1992) - et al.
Disinfection by endodontic irrigants and dressings of experimentally infected dentinal tubules
Endod Dent Traumatol
(1990) - et al.
Microbiological evaluation of efficacy of chlorhexidine in sustained release device for dentine sterilization
Int Endod J
(1992) - et al.
In vitro susceptibility of Candida albicans to four disinfectants and their combinations
Int Endod J
(1999) - et al.
The effect of chlorhexidine gluconate irrigation on the root canal flora of freshly extracted necrotic teeth
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(1982)
Antibacterial effects of various endodontic irrigants on selected anaerobic bacteria
Endod Dent Traumatol
Evaluation of the cleansing and disinfecting of the root canal with different irrigants, part I
Rev Assoc Odontol Argent
A comparison of 2.0% chlorhexidine gluconate and 5.25% sodium hypochlorite as antimicrobial endodontic irrigants
J Endodon
Antibacterial effects of endodontic irrigants on black-pigmented Gram-negative anaerobes and facultative bacteria
J Endodon
Efficacy of sustained release device containing chlorhexidine and Ca(OH)2 in preventing secondary infection of dentinal tubules
Int Endod J
Cited by (43)
Temperature dependent physicochemical studies propylene and hexylene glycols in methanol solutions of chlorhexidine
2021, Journal of Molecular LiquidsInfluence of dentin from the root canal walls and the pulp chamber floor on the pH of intracanal medicaments
2013, Journal of EndodonticsCitation Excerpt :Further research is needed to expand our knowledge and understanding of this interaction. The combination of Ca(OH)2 and 2% CHX gel has also been widely investigated and is recommended as an interappointment medicament (22–28). The presence of CHX may add substantivity to the combination because of its ability to remain in dentin (23).
Influence of 2% chlorhexidine gel on calcium hydroxide ionic dissociation and its ability of reducing endotoxin
2011, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and EndodontologyCitation Excerpt :The pH values of the solutions with samples containing calcium hydroxide did not show considerable differences, whereas the pH of 2% chlorhexidine gel varied from 5.50 to 6.88, as expected and in accordance with values found in the literature.24 Despite the low pH values shown in group III (2% chlorhexidine gel), the pH of the mixture of chlorhexidine with calcium hydroxide in group II did not differ from the pH values of calcium hydroxide used with an aqueous vehicle (group I), which is corroborated by earlier studies.14,25 The calcium hydroxide pastes released calcium ions in all periods of the study.
The effect of contaminating media on the static and dynamic mechanical resilience of dental implant abutments' screws: In vitro study
2023, Clinical Implant Dentistry and Related ResearchAnti-inflammatory Potential of Intracanal Medicament Containing Oregano Essential Oil
2022, ECS Transactions
This project was supported by grants from Dalhousie University, Halifax, Nova Scotia, Canada.