| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1
* Experimental Cell Research Program, Methodist Research Institute, Indianapolis, Indiana 46202, USA;
Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA;
Department of Microbiology-Immunology and R. H. Lurie Cancer Center, Northwestern University Medical School, Chicago, Illinois 60611, USA;
§ Department of Biochemistry, Lipid and Lipoprotein Research Group, University of Alberta, Edmonton, Alberta, T6H 5M3, Canada; and
¶ Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
1Correspondence: Experimental Cell Research Program, Methodist Research Institute, 1701 N. Senate Ave., Indianapolis, IN 46202, USA. E-mail: dkenglish{at}msn.com
Recent studies have identified factors responsible for angiogenesis
within developing tumors, but mediators of vessel formation at sites of
trauma, injury, and wound healing are not clearly established. Here we
show that sphingosine 1-phosphate (S1P) released by platelets during
blood clotting is a potent, specific, and selective endothelial cell
chemoattractant that accounts for most of the strong endothelial cell
chemotactic activity of blood serum, an activity that is markedly
diminished in plasma. Preincubation of endothelial cells with pertussis
toxin inhibited this effect of S1P, demonstrating the involvement of a
G
i-coupled receptor. After S1P-induced
migration, endothelial cells proliferated avidly and differentiated
forming multicellular structures suggestive of early blood vessel
formation. S1P was strikingly effective in enhancing the ability of
fibroblast growth factor to induce angiogenesis in the avascular mouse
cornea. Our results show that blood coagulation initiates endothelial
cell angiogenic responses through the release of S1P, a potent
endothelial cell chemoattractant that exerts its effects by activating
a receptor-dependent process.—English, D., Welch, Z., Kovala, A. T., Harvey, K., Volpert, O. V., Brindley, D. N., Garcia,
J. G. N. Sphingosine 1-phosphate released from platelets
during clotting accounts for the potent endothelial cell chemotactic
activity of blood serum and provides a novel link between hemostasis
and angiogenesis.
Key Words: lipid mediators • vascular endothelium • angiogenesis • endothelial cell migration • hemostasis • S1P
This article has been cited by other articles:
|
|
 |
|
  S.-C. Su, E. A. Mendoza, H.-i. Kwak, and K. J. Bayless Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing Am J Physiol Cell Physiol, November 1, 2008; 295(5): C1215 - C1229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Heller, Q. Chang, G. Ehrlich, S. N. Hsieh, S. M. Schoenwaelder, P. J. Kuhlencordt, K. T. Preissner, E. Hirsch, and R. Wetzker Overlapping and distinct roles for PI3K{beta} and {gamma} isoforms in S1P-induced migration of human and mouse endothelial cells Cardiovasc Res, October 1, 2008; 80(1): 96 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Machesky, G. Zhang, B. Raghavan, P. Zimmerman, S. L. Kelly, A. H. Merrill Jr., W. J. Waldman, J. R. Van Brocklyn, and J. Trgovcich Human Cytomegalovirus Regulates Bioactive Sphingolipids J. Biol. Chem., September 19, 2008; 283(38): 26148 - 26160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Ye Lysophospholipid signaling in the function and pathology of the reproductive system Hum. Reprod. Update, September 1, 2008; 14(5): 519 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ho-Tin-Noe, T. Goerge, S. M. Cifuni, D. Duerschmied, and D. D. Wagner Platelet Granule Secretion Continuously Prevents Intratumor Hemorrhage Cancer Res., August 15, 2008; 68(16): 6851 - 6858. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Miller, S. E. Alvarez, S. Spiegel, and D. A. Lebman Sphingosine Kinases and Sphingosine-1-Phosphate Are Critical for Transforming Growth Factor {beta}-Induced Extracellular Signal-Regulated Kinase 1 and 2 Activation and Promotion of Migration and Invasion of Esophageal Cancer Cells Mol. Cell. Biol., June 15, 2008; 28(12): 4142 - 4151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takabe, S. W. Paugh, S. Milstien, and S. Spiegel "Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets Pharmacol. Rev., June 1, 2008; 60(2): 181 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K. Wacker, S. K. Alford, E. A. Scott, M. Das Thakur, G. D. Longmore, and D. L. Elbert Endothelial Cell Migration on RGD-Peptide-Containing PEG Hydrogels in the Presence of Sphingosine 1-Phosphate Biophys. J., January 1, 2008; 94(1): 273 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Roviezzo, A. Di Lorenzo, M. Bucci, V. Brancaleone, V. Vellecco, M. De Nardo, D. Orlotti, R. De Palma, F. Rossi, B. D'Agostino, et al. Sphingosine-1-Phosphate/Sphingosine Kinase Pathway Is Involved in Mouse Airway Hyperresponsiveness Am. J. Respir. Cell Mol. Biol., June 1, 2007; 36(6): 757 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhao, S. K. Kalari, P. V. Usatyuk, I. Gorshkova, D. He, T. Watkins, D. N. Brindley, C. Sun, R. Bittman, J. G. N. Garcia, et al. Intracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells: ROLE OF LIPID PHOSPHATE PHOSPHATASE-1 AND SPHINGOSINE KINASE 1 J. Biol. Chem., May 11, 2007; 282(19): 14165 - 14177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Novgorodov, M. El-Alwani, J. Bielawski, L. M. Obeid, and T. I. Gudz Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration FASEB J, May 1, 2007; 21(7): 1503 - 1514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kunisawa, Y. Kurashima, M. Gohda, M. Higuchi, I. Ishikawa, F. Miura, I. Ogahara, and H. Kiyono Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production Blood, May 1, 2007; 109(9): 3749 - 3756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ochi, Y. Momose, K. Oyama, and W. R. Giles Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents Cardiovasc Res, April 1, 2006; 70(1): 88 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kobayashi, T. Nishi, T. Hirata, A. Kihara, T. Sano, Y. Igarashi, and A. Yamaguchi Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner J. Lipid Res., March 1, 2006; 47(3): 614 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gonzalez, R. Kou, and T. Michel Rac1 Modulates Sphingosine 1-Phosphate-mediated Activation of Phosphoinositide 3-Kinase/Akt Signaling Pathways in Vascular Endothelial Cells J. Biol. Chem., February 10, 2006; 281(6): 3210 - 3216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kisucka, C. E. Butterfield, D. G. Duda, S. C. Eichenberger, S. Saffaripour, J. Ware, Z. M. Ruggeri, R. K. Jain, J. Folkman, and D. D. Wagner Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage PNAS, January 24, 2006; 103(4): 855 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mehta and A. B. Malik Signaling Mechanisms Regulating Endothelial Permeability Physiol Rev, January 1, 2006; 86(1): 279 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, X.-P. Xing, A. Holmes, C. Wadham, J. R. Gamble, M. A. Vadas, and P. Xia Activation of the Sphingosine Kinase-Signaling Pathway by High Glucose Mediates the Proinflammatory Phenotype of Endothelial Cells Circ. Res., October 28, 2005; 97(9): 891 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Wilkes, T. M. Egan, and H. Y. Reynolds Lung Transplantation: Opportunities for Research and Clinical Advancement Am. J. Respir. Crit. Care Med., October 15, 2005; 172(8): 944 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Hait, S. Sarkar, H. Le Stunff, A. Mikami, M. Maceyka, S. Milstien, and S. Spiegel Role of Sphingosine Kinase 2 in Cell Migration toward Epidermal Growth Factor J. Biol. Chem., August 19, 2005; 280(33): 29462 - 29469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Goparaju, P. S. Jolly, K. R. Watterson, M. Bektas, S. Alvarez, S. Sarkar, L. Mel, I. Ishii, J. Chun, S. Milstien, et al. The S1P2 Receptor Negatively Regulates Platelet-Derived Growth Factor-Induced Motility and Proliferation Mol. Cell. Biol., May 15, 2005; 25(10): 4237 - 4249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tolle, B. Levkau, P. Keul, V. Brinkmann, G. Giebing, G. Schonfelder, M. Schafers, K. v. W. Lipinski, J. Jankowski, V. Jankowski, et al. Immunomodulator FTY720 Induces eNOS-Dependent Arterial Vasodilatation via the Lysophospholipid Receptor S1P3 Circ. Res., April 29, 2005; 96(8): 913 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Allende, T. Sasaki, H. Kawai, A. Olivera, Y. Mi, G. van Echten-Deckert, R. Hajdu, M. Rosenbach, C. A. Keohane, S. Mandala, et al. Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720 J. Biol. Chem., December 10, 2004; 279(50): 52487 - 52492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Roviezzo, F. Del Galdo, G. Abbate, M. Bucci, B. D'Agostino, E. Antunes, G. De Dominicis, L. Parente, F. Rossi, G. Cirino, et al. Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate PNAS, July 27, 2004; 101(30): 11170 - 11175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Dudek, J. R. Jacobson, E. T. Chiang, K. G. Birukov, P. Wang, X. Zhan, and J. G. N. Garcia Pulmonary Endothelial Cell Barrier Enhancement by Sphingosine 1-Phosphate: ROLES FOR CORTACTIN AND MYOSIN LIGHT CHAIN KINASE J. Biol. Chem., June 4, 2004; 279(23): 24692 - 24700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Peng, P. M. Hassoun, S. Sammani, B. J. McVerry, M. J. Burne, H. Rabb, D. Pearse, R. M. Tuder, and J. G. N. Garcia Protective Effects of Sphingosine 1-Phosphate in Murine Endotoxin-induced Inflammatory Lung Injury Am. J. Respir. Crit. Care Med., June 1, 2004; 169(11): 1245 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Langlois, D. Gingras, and R. Beliveau Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation Blood, April 15, 2004; 103(8): 3020 - 3028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Olivera, H. M. Rosenfeldt, M. Bektas, F. Wang, I. Ishii, J. Chun, S. Milstien, and S. Spiegel Sphingosine Kinase Type 1 Induces G12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors J. Biol. Chem., November 21, 2003; 278(47): 46452 - 46460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Liu, R. E. Toman, S. K. Goparaju, M. Maceyka, V. E. Nava, H. Sankala, S. G. Payne, M. Bektas, I. Ishii, J. Chun, et al. Sphingosine Kinase Type 2 Is a Putative BH3-only Protein That Induces Apoptosis J. Biol. Chem., October 10, 2003; 278(41): 40330 - 40336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Licht, L. Tsirulnikov, H. Reuveni, T. Yarnitzky, and S. A. Ben-Sasson Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3) Blood, September 15, 2003; 102(6): 2099 - 2107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. GRATZINGER, S. CANOSA, B. ENGELHARDT, and J. A. MADRI Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho FASEB J, August 1, 2003; 17(11): 1458 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Schaphorst, E. Chiang, K. N. Jacobs, A. Zaiman, V. Natarajan, F. Wigley, and J. G. N. Garcia Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products Am J Physiol Lung Cell Mol Physiol, July 1, 2003; 285(1): L258 - L267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Manegold, J. Hutter, S. A. Pahernik, K. Messmer, and M. Dellian Platelet-endothelial interaction in tumor angiogenesis and microcirculation Blood, March 1, 2003; 101(5): 1970 - 1976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Kim, H. M. Lee, T. H. Lee, C. Kang, H. K. Kleinman, and Y. S. Gho Extracellular Membrane Vesicles from Tumor Cells Promote Angiogenesis via Sphingomyelin Cancer Res., November 1, 2002; 62(21): 6312 - 6317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Cummings, N. L. Parinandi, A. Zaiman, L. Wang, P. V. Usatyuk, J. G. N. Garcia, and V. Natarajan Phospholipase D Activation by Sphingosine 1-Phosphate Regulates Interleukin-8 Secretion in Human Bronchial Epithelial Cells J. Biol. Chem., August 9, 2002; 277(33): 30227 - 30235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Spiegel and S. Milstien Sphingosine 1-Phosphate, a Key Cell Signaling Molecule J. Biol. Chem., July 12, 2002; 277(29): 25851 - 25854. [Full Text] [PDF]
|
|
|
|
 |
|
 V. Vouret-Craviari, C. Bourcier, E. Boulter, and E. Van Obberghen-Schilling Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells J. Cell Sci., June 15, 2002; 115(12): 2475 - 2484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Rikitake, K.-i. Hirata, S. Kawashima, M. Ozaki, T. Takahashi, W. Ogawa, N. Inoue, and M. Yokoyama Involvement of Endothelial Nitric Oxide in Sphingosine-1-Phosphate-Induced Angiogenesis Arterioscler. Thromb. Vasc. Biol., January 1, 2002; 22(1): 108 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. ROSENFELDT, J. P. HOBSON, M. MACEYKA, A. OLIVERA, V. E. NAVA, S. MILSTIEN, and S. SPIEGEL EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration FASEB J, December 1, 2001; 15(14): 2649 - 2659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lum Lysophospholipids in the regulation of endothelial barrier function Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1335 - L1336. [Full Text] [PDF]
|
|
|
|
|
|
T. Levade, N. Auge, R. J. Veldman, O. Cuvillier, A. Negre-Salvayre, and R. Salvayre Sphingolipid Mediators in Cardiovascular Cell Biology and Pathology Circ. Res., November 23, 2001; 89(11): 957 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Liu, A. D. Verin, P. Wang, R. Day, R. P. Wersto, F. J. Chrest, D. K. English, and J. G. N. Garcia Differential Regulation of Sphingosine-1-Phosphate- and VEGF-Induced Endothelial Cell Chemotaxis . Involvement of Gialpha 2-Linked Rho Kinase Activity Am. J. Respir. Cell Mol. Biol., June 1, 2001; 24(6): 711 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. English, J. G.N. Garcia, and D.N. Brindley Platelet-released phospholipids link haemostasis and angiogenesis Cardiovasc Res, February 16, 2001; 49(3): 588 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Paik, S.-s. Chae, M.-J. Lee, S. Thangada, and T. Hla Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of alpha vbeta 3- and beta 1-containing Integrins J. Biol. Chem., April 6, 2001; 276(15): 11830 - 11837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ancellin, C. Colmont, J. Su, Q. Li, N. Mittereder, S.-S. Chae, S. Stefansson, G. Liau, and T. Hla Extracellular Export of Sphingosine Kinase-1 Enzyme. SPHINGOSINE 1-PHOSPHATE GENERATION AND THE INDUCTION OF ANGIOGENIC VASCULAR MATURATION J. Biol. Chem., February 15, 2002; 277(8): 6667 - 6675. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
